A METHOD OF TREATING SJÖGREN’S SYNDROME IN A PATIENT ELIGIBLE FOR TREATMENT IS PROVIDED INVOLVING ADMINISTERING AN EFFECTIVE AMOUNT OF AN ANTAGONIST THAT BINDS TO A B-CELL SURFACE MARKER TO THE PATIENT TO PROVIDE SIGNIFICANT IMPROVEMENT OVER BASELINE IN TWO OR MORE OF DRYNESS, FATIGUE, AND JOINT PAIN ON A VISUAL ANALOGUE SCALE, AND AN ARTICLE OF MANUFACTURE THEREFOR. METHODS AND ARTICLES ARE ALSO PROVIDED INVOLVING TREATING SJÖGREN’S SYNDROME IN A SUBJECT ELIGIBLE FOR TREATMENT IS PROVIDED INVOLVING ADMINISTERING AN EFFECTIVE AMOUNT OF AN ANTIBODY THAT BINDS TO A B-CELL SURFACE MARKER TO THE SUBJECT TO PROVIDE AN INITIAL EXPOSURE AND A SUBSEQUENT EXPOSURE TO THE ANTIBODY WITHIN CERTAIN DOSING REGIMENS AND AN ARTICLE OF MANUFACTURE THEREFOR.
