Mariappan V. Chelliah;Samuel Chackalamannil;Yuguang Wang;Yan Xia
发明人:
Samuel Chackalamannil,Mariappan V. Chelliah,Yuguang Wang,Yan Xia
申请号：
US13404462
公开号：
US20120157403A1
申请日:
2012.02.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Heterocyclic-substituted tricyclics of the formulaor a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein represents an optional double bond, the dotted line is optionally a bond or no bond, resulting in a double bond or a single bond, as permitted by the valency requirement and wherein E, A, G M, Het, B, X, R3, R10, R11, R32 and R33 are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.
