This invention provides a medical device for target tumor therapy using either surface plasma resonance of nanoparticle or photosensitizer excited by lasers. The system includes: a IR laser unit an external connecting delivery fiber connected to a hand piece and a temperature auto-controlled unit with feedback device to produce pulse train output laser to achieve constant tumor surface temperature increase. It may use optimally selected multiple wavelength lasers for a 3D laser therapy. The solid state laser used in this invention may be cw or pulsed mode having wavelength range of 650 to 1350 nm, output power of 0.01 to 20 W. The nanoparticles used in this invention include Au, Ag or Au/Ag combined particle having various size and shapes. It includes in particular gold nanorods with an aspect ratio of (3.0 - 10.0), or a silica-gold shell, having surface conjugated by PEG and anti-body. The photosensitizers include Chlorin-e6-Chlrophyllin-A-Zic-complex, bateriochlorin and texaphyrin.一種藉由奈米粒子表面電漿共振(surface plasma resonance)激發或光敏劑的雷射靶向性腫瘤治療系統。其包括:紅外光波段之雷射裝置;外接傳輸光纖與一個手柄;一個溫控自動系統;以及一個信號回饋裝置,產生脈沖式(pulse train)輸出光,達到自動溫控的需要,使腫瘤組織表面層上升溫度維持定值。也可經由多波長之最佳選擇,達到雷射光在生物組織立體化療效。該固體雷射係連續出光或脈衝出光,波長(650-1350)nm,輸出功率(0.01-20)瓦。本創作之奈米粒子包括金、銀或金銀組合所構成不同大小,任何形狀之奈米粒子,特別是包括一種奈米金棒長寬比為(3.0-10.0)或奈米金矽殼(gold-silica shell)。奈米粒子其表面也可修飾PEG (polyethylene glycol)或抗體(anti-body)。本創作之光敏劑包括菌綠素(bateriochlorin),氯-e6-葉綠素複合物(Chlorin-e6-Chlrophyllin-A-Zinc-complex)或特沙弗林(texaphyrin)。(100)‧‧‧雷射裝置(100-a)‧‧‧連接頭(101)‧‧‧傳輸光纖(102)‧‧‧手柄(103)‧‧‧可調焦透鏡組(104)‧‧‧快門(105)‧‧‧電控馬達(106),109)‧‧‧信號連接線(107)‧‧‧溫控自動系統(107-a)‧‧‧讀溫計(107-b)‧‧‧信號回饋裝置(105)‧‧‧電控馬達(108-a,108-b)‧‧‧熱電耦(120)‧‧‧腫瘤組織
