QI JUN,TANAKA MINORU,ROBERTS JUSTIN M,BRADNER JAMES E
申请号：
IN201817016494
公开号：
IN201817016494A
申请日:
2018.05.02
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention provides bivalent inhibitors of BET bromodomains such as compounds of Formulae (I) (II) (III) (IV) (V) and (VI). Some bromdomain containing proteins (e.g. BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g. BRD4 comprises BDl and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions and can therefore can be to treat diseases or conditions associated with bromodomain containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds as well as methods of using the inventive compounds.
