PROBLEM TO BE SOLVED: To provide a method for producing a pharmaceutical composition containing an active ingredient having at least either one of adherability or aggregability using wet granulation with high production efficiency as compared with conventional methods, to provide a pharmaceutical composition containing drug particles in which aggregation is suppressed, and to provide an orally disintegrating tablet comprising the pharmaceutical composition.SOLUTION: A method for producing a pharmaceutical composition comprises preparing a drug-containing solution which contains the following components (a)-(c): component (a) is an active ingredient having at least either one of adherability and aggregability (b) is at least one compound component selected from the group consisting of sodium stearyl fumarate and magnesium stearate and (c) is water as well as coating the obtained drug-containing solution on a nuclear particle using a granulator and granulating.COPYRIGHT: (C)2015,JPO&INPIT【課題】付着性及び凝集性の少なくとも一方を有する活性成分を含む医薬用組成物を、湿式造粒を用いて従来に比して高い製造効率で得られる製造方法、凝集が抑制された薬物粒子を含む医薬用組成物、及び該医薬用組成物を含む口腔内崩壊錠の提供。【解決手段】下記成分(a)~(c)を含む薬物含有液を調製することと、得られた薬物含有液を造粒機を用いて核粒子上にコーティングして造粒することと、を含む医薬用組成物の製造方法。成分(a):付着性及び凝集性の少なくとも一方を有する活性成分成分(b):フマル酸ステアリルナトリウム及びステアリン酸マグネシウムからなる群より選択される少なくとも1つの化合物成分(c):水【選択図】なし
