An activated antigen-presenting cell capable of inducing an immunocompetent cellincluding a disease antigen-specific CD8+CTL and/or a γδT cell and/or with good efficiency； a pharmaceutical comprisingthe activated antigen-presenting cell； a therapeutic/prophylactic methodusing the activated antigen-presenting cell； a method for induction of an immunocompetentcell including a disease antigen-specific CD8+CTL and/or a γδTcell which is induced by using the activated antigen-presenting cell； an immunocompetentcell induced by the method； a pharmaceutical comprising the immunocompetentcell； and a therapeutic/prophylactic method using the immunocompetent cell.An antigen-presenting cell is sensitized with a disease antigen and also co-sensitizedwith bisphosphonate, thereby producing an increased number of a disease antigen-specificCD8+CTL and/or a γδT cell at a higher ratio compared to a method withoutco-sensitization with bisphosphonate.
