CARPENTER, MELISSA K.,DENHAM, JERROD J.,INOKUMA, MARGARET S.,THIES, SCOTT R.
申请号：
CA2451486
公开号：
CA2451486C
申请日:
2002.06.20
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
This disclosure provides improved methods for obtaining populations of neuralprogenitor cells and differentiated neurons from pluripotent stem cells. Thetechnology can be used to produce progenitors that proliferate through atleast 40 doublings, while maintaining the ability to differentiate into avariety of different neural phenotypes. Cell populations have been obtainedthat contain a high proportion of cells staining for tyrosine hydroxylase,which is a feature of dopaminergic neurons. The neural progenitors andterminally differentiated neurons of this invention can be generated in largequantities for use in drug screening and the treatment of clinically importantneurological disorders, such as Parkinson's disease.
