Hong Jin,Roderick Tang,Shengqiang Li,Martin Bryant,David Kirkwood Clarke,Peter Palese
申请号：
US13488700
公开号：
US20120308602A1
申请日:
2012.06.05
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
