The present invention provides a pharmaceutical composition comprising a probiotic and a prebiotic for alleviating symptoms associated with infections such as neonatal sepsis and pneumonia in neonates and infants. More particularly, the pharmaceutical composition comprises at least one Lactillobacillus specie(s) as a probiotic and at least one oligosaccharide or at least one polysaccharide as a pre-biotic. The present inventon further provides a method of treatment of neonatal sepsisand pneumonia comprising administering an effective amount of the pharmaceutical composition to neonates and infants in need thereof.