BOZENA EWA ADAMCZYK,COLIN THOMAS LINDLEY,MARK HENRY SAUNDERS,MICHAEL READER,MIRKA SCARATI,NICOLA ELIZABETH WILSHER,PAUL ANTHONY BAGULEY,ROBERT CRAIG MELLING
申请号：
BR112019019948
公开号：
BR112019019948A2
申请日:
2018.04.20
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
this invention relates to the compound (2r) -2- (6- {5-chloro-2 - [(oxan-4-yl) amino] pyrimidin-4-yl} -1-oxo-2,3-dihydro- 1h-isoindol-2-yl) -n - [(1s) -1- (3-fluoro-5-methoxyphenyl) -2-hydroxyethyl] propanamide and, in particular, to new physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process and new formulations containing the compound, as well as therapeutic uses of the compound.esta invenção refere-se ao composto (2r)-2-(6-{5-cloro-2-[(oxan-4-il)amino]pirimidin-4-il}-1-oxo-2,3-dihidro-1h-isoindol-2-il)-n-[(1s)-1-(3-fluoro-5-metoxifenil)-2-hidroxietil]propanamida e, em particular, a novas formas físicas do composto, um processo para preparar o composto e intermediários sintéticos para uso no processo e novas formulações contendo o composto, assim como usos terapêuticos do composto.
