The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.本發明提供與人類胰高血糖素受體(稱為GCGR)結合之抗體及使用彼等之方法。根據本發明之特定具體實例，彼等抗體係與人類GCGR結合之完全人類抗體。本發明抗體可用於降低血糖量及血酮量，且亦可用於治療與一或多種GCGR生物活性相關之疾病與失調症，包括治療糖尿病、糖尿病酮酸症及與糖尿病相關之長期併發症、或其部分特徵為血糖量升高之代謝失調症。
