A system for medical tubing detection and management could include an infusion manifold housing having at least one fluid channel therethrough. At least one fluid input port could be provided in the infusion manifold housing and could be configured to connect fluidically to illuminated medical tubing and communicate with the at least one fluid channel through the infusion manifold housing. A fluid output port could be provided in the infusion manifold housing and be configured to be in fluidic communication with the at least one fluid channel through the infusion manifold housing. At least one photosensor could be provided in the infusion manifold housing and be configured to receive light from the illuminated medical tubing and the fluid output port could be configured to connect fluidically to fluid output tubing.