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Derivados aminofosfínicos útiles en el tratamiento del dolor
专利权人:
PHARMALEADS
发明人:
ROQUES, BERNARD,PORAS, HERVÉ,FOURNIE-ZALUSKI, MARIE-CLAUDE
申请号:
ES09780902
公开号:
ES2533851T3
申请日:
2009.07.22
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of general formula (I): R1-NH-CH (R2) -P (> = O) (OR3) -CH2-C (R4) (R5) -CONH-CH (R6) -COOR7 (I) or a pharmaceutically acceptable salt thereof, for which: - R1 represents a -C (> = O) -OC (R8) (R9) -OC (> = O) -R 10, wherein - R8 and R9 represent, independently of one another, a hydrogen atom or an alkyl group, - and R10 represents an alkyl group, - R2 represents: - straight or branched alkyl group comprising 1 to 6 carbon atoms, - a phenyl group - R3 represents a hydrogen atom or a group of formula -C (R12) (R13) -OC (> = O) -R 14, in which - R12 and R13 represent, independently of each other, a hydrogen atom or alkyl group, - and R 14 represents an alkyl group - R5 represents a hydrogen atom and R4 represents: - a benzyl optionally substituted in the phenyl nucleus by: - ​​1 to 5 atom (s) such halogen (s) such as fluorine or bromine - OR15 or SR15 group in which R15 represents a hydrogen atom, a benzyl group or a saturated or unsaturated, linear or branched hydrocarbon chain comprising from 1 to 4 carbon atoms - an amino group - CF 3 - a phenyl group or - a heteroaromatic ring of 5 or 6 ring members - R4 and R5 form together with the carbon that carries: - a saturated hydrocarbon ring 5 or 6-membered ring or - a piperidine, being the nitrogen at position 4 and optionally being substituted by: * one -SO 2 Ph group * CF 3 * An alkyl group of C1 to C4 * An acyl group of C1 to C4 * A phenyl or benzyl optionally substituted by one or more atom (s) halogen, an alkyl group of C1 to C4 or an alkoxy group of C1 to C4 or * an aromatic heterocycle such as a pyridine or pyrimidine, optionally substituted with an alkyl group of C1 to C4 or an alkoxy group of C1 to C4 - R6 represents: - straight or branched alkyl group comprising 1 to 6 carbon atoms and optionally substituted with: - OR16 group wherein R16 represents a hydrogen atom, - R7 represents a radical selected from the group consisting of a hydrogen atom, benzyl, C2 to C4, -CHR18-COOR 19, -CHR18-OC (> = O) -CHR
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