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Solid dosage form of HIV protease inhibitors
专利权人:
发明人:
申请号:
EP11179139.8
公开号:
EP2564832A1
申请日:
2011.08.29
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
A pharmaceutical dosage form suitable for oral administration comprising a solid dispersion of at least one HIV protease inhibitor, at least one first pharmaceutically acceptable water-soluble polymer (A), at least one second pharmaceutically acceptable water-soluble polymer (B), and optionally at least one pharmaceutically acceptable surfactant,wherein the at least one first pharmaceutically acceptable water-soluble polymer (A) has a glass transition temperature (Tg) of at least 50°C and is present in an amount of 10% to 49% by weight of the dosage form and is not polyvinylpyrrolidone (PVP) or hydroxypropyl methylcellulose (HPMC), and wherein the at least one second pharmaceutically acceptable water-soluble polymer (B) has a Tg of less than 50°C.
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