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SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-PHTHALIMIDES AND 1-OXOISOINDOLINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
专利权人:
WARREN;CELGENE CORPORATION
发明人:
MULLER, GEORGE W.,STIRLING, DAVID I.,CHEN, ROGER SHEN-CHU
申请号:
HU0003217
公开号:
HU229578B1
申请日:
1998.05.28
申请国别(地区):
HU
年份:
2014
代理人:
摘要:
1. A 2,6-dioxopiperidine selected from the group consisting of (a) a compound of the formula: <;CHEM>; in which: one of X and Y is C=O and the other of X and Y is C=O or CH2; (i) each of R<;1>;, R<;2>;, R<;3>;, and R<;4>;, independently of the others, is halo, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or (ii) one of R<;1>;, R<;2>;, R<;3>;, and R<;4>; is -NHR<;5>; and the remaining of R<;1>;, R<;2>;, R<;3>;, and R<;4>; are hydrogen; R<;5>; is hydrogen, alkyl of 1 to 8 carbon atoms, or CO-R<;7>;-CH(R<;10>;)NR<;8>;R<;9>;; R<;6>; is hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro; R<;7>; is m-phenylene or p-phenylene or -(CnH2n)- in which n has a value of 0 to 4; each of R<;8>; and R<;9>; taken independently of the other is hydrogen or alkyl of 1 to 8 carbon atoms, or R<;8>; and R<;9>; taken together are tetramethylene, pentamethylene, hexamethylene, or -CH2CH2XCH2CH2- in which X is -O-, -S- or -NH-; R<;10>; is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl; and (b) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.
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