JUNG, Myung Ho,정명호,KIM, Nam Doo,김남두,CHOI, Ji Eun,최지은,KIM, Dae Kwon,김대권,YUN, Jung Yeon,윤정연,MA, Da Hoon,마다훈,CHUNG, So Hyun,정소현,JEON, Hyeon Ho,전현호,RYU, Hee Sun,류희선,KIM, Hyun Kyung,김현경,KIM, Hwan,김환,SON, J
申请号：
KRKR2020/000944
公开号：
WO2020/149715A1
申请日:
2020.01.20
申请国别(地区):
KR
年份:
2020
代理人:
摘要：
The present invention relates to a pyrrolopyridine derivative and a pharmaceutical composition comprising same as an active ingredient for prevention or treatment of a protein kinase-related disease. The pyrrolopyridine derivative has excellent inhibitory activity against various protein kinases including LRRK2, DYRK1, and CLK1 and exhibits an excellent suppressive effect on the growth of triple-negative breast cancer cells. A pharmaceutical composition comprising same as an active ingredient can be advantageously used for treating or preventing protein kinase-related diseases, inter alia, cancer, degenerative brain diseases, and inflammatory diseases, and specifically for treating triple-negative breast cancer.La présente invention concerne un dérivé de pyrrolopyridine et une composition pharmaceutique le comprenant en tant que principe actif pour la prévention ou le traitement d'une maladie liée à la protéine kinase. Le dérivé de pyrrolopyridine présente une excellente activité inhibitrice vis-à-vis de plusieurs protéines kinases notamment LRRK2, DYRK1 et CLK1 et présente un excellent effet inhibiteur sur la croissance de cellules du cancer du sein triple-négatif. Une composition pharmaceutique comprenant ledit dérivé de pyrrolopyridine en tant que principe actif peut être utilisée de manière avantageuse pour traiter ou prévenir des maladies liées à la protéine kinase, entre autres, le cancer, des maladies cérébrales dégénératives et des maladies inflammatoires, et en particulier pour traiter le cancer du sein triple-négatif.피롤로피리딘 유도체 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 피롤로피리딘 유도체는 LRRK2, DYRK1, 및 CLK1을 포함하는 다양한 단백질 키나아제에 대한 억제활성이 우수하고, 삼중음성 유방암 세포의 증식을 억제하는 효과가 우수하므로, 이를 유효성분으로 함유하는 약학적 조성물은 단백질 키나아제 관련 질환, 특히, 암, 퇴행성 뇌질환 및 염증질환의 치료 또는 예방에 유용하게 사용될 수 있고, 구체적으로, 삼중음성 유방암의 치료에 유용하게 사용될 수 있다.
