Harvey Lodish,Hidde L. Ploegh,Hsiang-Ying Sherry Lee,Jiahai Shi,Lenka Hoffman,Novalia Pishesha
申请号：
US15934177
公开号：
US20180280440A1
申请日:
2018.03.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for the in vitro production of enucleated red blood cells and the enucleated red blood cells thus prepared are provided. Such enucleated red blood cells may express a sortaggable surface protein, which allows for surface modification in the presence of a sortase. Also described herein are surface modified enucleated red blood cells, e.g., conjugated with an agent of interest such as a peptide, a detectable label, or a chemotherapeutic agent, and uses thereof in delivering the agent to a subject.
