MICHAEL NEU,MARKUS TSCHOEPE,CARSTEN WEBER,LAURA REDDEN,WOLFGANG FRAUNHOFER,MARTIN GASTENS,ALEXANDER FEICK,SUSAN K. PAULSON,TONG ZHU
申请号：
PT11839071
公开号：
PT2637690T
申请日:
2011.11.11
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen-binding portion thereof, or a biosimilar thereof.
