BROCK T. SHIREMAN,CHRISTINE F. GELIN,JEANNIE M. ZIFF,TERRY P. LEBOLD
申请号：
BR112015022294
公开号：
BR112015022294A2
申请日:
2014.03.12
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract the present invention is directed to compounds of formula i: wherein x is n or cr1； y is not or cr 2； R 1 is h, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl； R 2 is h, alkyl, alkoxy, or halo； z is not or； R 3 is h, alkyl, alkoxy, halo, or triazolyl； R4 is h or alkyl； or r3 and r4, together with the atoms to which they are attached, form a 6- membered aryl ring or a 5- or 6-membered heteroaryl ring； R5 is pyridyl, pyrazinyl, or pyrimidinyl, wherein the pyridyl, pyrazinyl, or pyrimidinyl is optionally substituted with halo or alkyl； and n is 1 or 2. methods of making the compounds of formula are also described. the invention also relates to pharmaceutical compositions comprising compounds of formula i. methods of using the compounds of the invention are also within the scope of the invention. "Substituted 2-azabicycles and their use as orexin receptor modulators" The present invention is directed to the compounds of formula I: wherein x is n or cr1； y is n or cr2； R1 is h, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl or pyrazolyl； R2 is h, alkyl, alkoxy or halo； z is nh or o； R3 is h, alkyl, alkoxy, halo or triazolyl； R4 is h or alkyl； or R3 and R4, together with the atoms to which they are attached, form a 6-membered aryl ring or a 5 or 6-membered heteroaryl ring； R5 is pyridyl, pyrazinyl or pyrimidinyl, wherein pyridyl, pyrazinyl or pyrimidinyl is optionally substituted by halo or alkyl； and n is 1 or 2. Methods for producing the compounds of formula I are also described. The invention also relates to pharmaceutical compositions comprising compounds of formula I. Methods of using the compounds of the invention are also within the scope of the invention.abstract the present invention is directed to compounds of formula i: i wherein x is n or cr1； y is n or cr2； r1 is h, alkoxy, halo, triazolyl, pyrimidinyl, oxazolyl, isoxazole, oxadiazolyl, or pyrazolyl； r2 is h, alkyl, alkoxy, or halo； z is n
