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Prion protein structure conversion inhibitor and its use
专利权人:
国立大学法人岐阜大学
发明人:
桑田 一夫,木村 力,武藤 淳二
申请号:
JP2011513378
公开号:
JP5665089B2
申请日:
2010.05.13
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
Provided is a novel compound which is capable of inhibiting the formation of an infectious prion protein via binding to a normal prion protein. Specifically provided is a compound represented by formula (1). In formula (1), X represents a carbon atom or a nitrogen atom; R1 and R2 may be either the same or different and represent a hydrogen atom, an oxygen atom, a halogen atom, a hydroxy group, a mercapto group, a cyano group, a carboxy group, a carbamoyl group, an alkoxycarbonyl group, an acyloxy group, an acyl group, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted amino group, etc.; and R3 to R6 may be either the same or different and represent a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, etc., provided that at least one of R1 and R2 represents a group other than hydrogen atom.
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