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Stable digestive enzyme compositions
专利权人:
Marco Marconi;Luigi Mapelli;Giovanni Ortenzi
发明人:
Giovanni Ortenzi,Marco Marconi,Luigi Mapelli
申请号:
US13019856
公开号:
US08562980B2
申请日:
2011.02.02
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.
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