Matthew Colin Thor Fyfe,Michael Knaggs,Premji Meghani,Stephen Malcolm Thom
申请号：
US15228945
公开号：
US09796742B2
申请日:
2016.08.04
申请国别(地区):
US
年份:
2017
代理人:
摘要：
There are provided compounds of formula I,wherein R1 to R5, X1, X2, Ar, L, A, A1, E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes Syk kinase and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
