Isolated epitope peptides derived from TOPK and immunogenic fragments thereof have an ability to induce cytotoxic T lymphocytes (CTLs) and thus are suitable for use in cancer immunotherapy, more particularly as cancer vaccines. The peptides of the present invention encompass both of peptides including a TOPK-derived amino acid sequence and modified versions thereof, in which one, two, or several amino acids are substituted, deleted, inserted and/or added, provided such modified versions have CTL inducibility. Further provided are polynucleotides encoding any of the aforementioned peptides as well as pharmaceutical compositions that include any of the aforementioned peptides or polynucleotides. The peptides, polynucleotides, and pharmaceutical compositions of this invention find particular utility in either or both of the treatment and prevention of cancers and tumors.La presente invención se refiere a los péptidos de epítopo aislado derivados de TOPK y fragmentos inmunogénicos del mismo tiene una habilidad para inducir linfocitos T citotóxicos (CTLs) y de esta manera son idóneos para su uso en inmunoterapia de cáncer, más particularmente como vacunas de cáncer. Los péptidos de la presente invención abarcan tanto péptidos que incluyen una secuencia de aminoácidos derivada de TOPK como versiones modificadas de la misma, en las que uno, dos, o muchos aminoácidos se sustituyen, eliminan, insertan y/o agregan, siempre y cuando tales versiones tengan inducción CTL.
