Disclosed is a vesicle composition containing (a) a lysophospholipid, (b) one or more substances selected from higher alcohols which are in a liquid state at 25°C and liquid higher fatty acids, (c) cholesterol or phytosterol and (d) purified water.提供有效的作為保存安定性良好,滲透感優異,不會發黏,保濕效果優異之皮膚外用劑之囊泡組成物。含有(a)溶血磷脂質(lysophospholipid)、(b)1種或2種以上選自於25℃為液狀之高級醇或液狀之高級脂肪酸、(c)膽固醇或植物甾醇、(d)精製水之囊泡組成物。