An denture sterilization device using TiO2 photocatalyst is provided, including one body and one lid pivotally installed on top of the body, inside the body a receiving space is provided for accommodating denture, and the lid is able to fittingly cover the receiving space correspondingly, in addition, a ultraviolet lamp set is equipped respectively at the bottom of the receiving space and the lid, and a light transmissive TiO2 photocatalyst reactive substrate is disposed in a corresponding side of the receiving space toward which the respective ultraviolet lamp is facing; therefore, by using the ultraviolet lamp set to irradiate the light transmissive TiO2 photocatalyst reactive substrate, the denture placed in the receiving space can be sterilized through the effect of photocatalyst.一種應用二氧化鈦光觸媒對假牙殺菌的裝置,包括有一本體及一樞設於本體頂部之蓋體,本體內部具有可供一假牙置放之容置空間,且蓋體可相對蓋合於容置空間上,而容置空間底部與蓋體底部分別設有一紫外線燈組,且於各紫外線燈組分別朝向容置空間之一側相對設置有一可透光之二氧化鈦光觸媒反應基板,並藉紫外線燈組照射可透光之二氧化鈦光觸媒反應基板,進而可對容設於容置空間中之假牙產生光觸媒殺菌作用。