#$%^&*AU2008229668B220130606.pdf#####- 15 Abstract A catheter for delivery of a therapeutic agent directly into a targeted tissue that reduces or substantially prevents retlux and back flow by providing rigidity and 5 strength via a stylet thereby eliminating the need for a guide or delivery sheath during positioning. The catheter has a flexible proximal section and a substantially rigid distal section formed from a plurality of distal subsections. The proximal and distal sections having decreasing outer diameters starting from the proximal end and advancing towards the distal end. The distal subsection closest to the distal end 10 providing an adjustable flow rate via multiple output ports defined radially therein while the distal end itself is closed off. 15 26'09lJR,va 17537.speiI51/2 -4 T ~ ~M ~ ii C 7 , II~z'-4 ~-I -'ml ~-+'~； 4N LIL.j r~4 K N~ I I 41 N H II It, 0
