An IGF-1 production promoter comprises, as an active ingredient: a Citrus depressa Hayata extract, preferably water and/or organic solvent extract of Citrus depressa Hayata fruit or leaves, a supercritical extract of Citrus depressa Hayata fruit or leaves, or a subcritical extract of Citrus depressa Hayata fruit or leaves, the Citrus depressa Hayata extract containing 0.3 mass% or more of polymethoxyflavonoid in solid basis, for example, a Citrus depressa Hayata extract containing 0.2 mass% or more of nobiletin and/or 0.1 mass% or more of tangeretin in solid basis； or polymethoxyflavonoid, such as nobiletin or tangeretin.
