A battery autoclaving system is provided including a battery pack having a housing, a battery cell disposed within the housing, and an isolation region disposed between the housing and the battery cell. The isolation region may be formed at least partially from at least one of a thermal insulating material, a phase change material or any combination thereof. The system may include a temperature sensor adapted to sense at least one of a temperature of the battery cell temperature of the isolation region. The system may include and an autoclave configured to receive a temperature indication from the temperature sensor and to inhibit autoclaving when the temperature indication exceeds a predetermined value.