Aranapakam M. Venkatesan,Roger A. Smith,Scott K. Thompson,Nicholas Laping,Bheemashankar Kulkarni,Gurulingappa Hallur,Vellarkad N. Viswanadhan,Muralidhar Pendyala,Raghava Reddy Kethiri,Rajiv Tyagi,Dhan
申请号：
US15021186
公开号：
US20160222014A1
申请日:
2014.09.05
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present application provides novel optionally substituted fused pyridine and pyrimidine bicyclic compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating FAK and/or Src activity by administering a therapeutically effective amount of one or more of the compounds to a subject. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the FAK and/or Src pathway. Advantageously, these compounds perform as dual FAK and/or Src inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.
