LADAVAC KOSTA,GUERRA RODRIGO E,KAZ DAVID,MANOHARAN VINOTHAN,RIEGER JENS B,KOLTZENBURG ROLAND SEBASTIAN,WEITZ DAVID A
申请号：
IN9264/DELNP/2012
公开号：
IN2012DN09264A
申请日:
2012.10.26
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention generally relates to foams and particles made from such foams for applications such as drug delivery. The foams or particles may comprise a pharmaceutically acceptable polymeric carrier. In some cases the foams may include colloidal particulates. A first aspect of the present invention is generally related to polymer based foams or particles containing pharmaceutically active agents. In some cases the foam or particle may contain smaller colloidal particulates therein. Such colloidal particulates may be used for example to limit the amount of material within certain regions of the foam or exclude pharmaceutically active agents from being located within certain portions of the foam which may useful for enhancing release of pharmaceutically active agents from the foam. In some cases the colloidal particulates may cause the foam or particle to have an unexpectedly high specific surface area. The foam in certain embodiments can exhibit a relatively high loading of the pharmaceutically active agent. The foam may be microcellular in certain instances. The foam may also be created using a supercritical fluid for example supercritical C0. For instance a precursor to the foam containing a pharmaceutically active agent a pharmaceutically acceptable polymeric carrier and colloidal particulates can be mixed with a foaming agent. The pressure may then be decreased thereby causing the foaming agent to expand and causing a foam to form. The foam may also be ground or milled or otherwise processed to form particles such as nanoparticles.
