YU, Henry,RICHARDSON, Thomas E.,DONNELLY, Marianne,NGUYEN, Ngan,JIANG, Xuliang
申请号：
ES14739012
公开号：
ES2657979T3
申请日:
2014.06.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I, ** Formula ** X is CR2； Y is O, S or NR； Z is N； each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur； or two R groups on the same atom are taken together with the atom to which they are attached to form a C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocyclic ring having 1 -4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur； Ring A is a fused C3-10 aryl, a saturated 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered fused heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or a fused 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur； R1 is -OCH3 or -OCD3； R2 is -OCH3, ** Formula ** R3 is -Br, each R4 is independently -R, halogen, -haloalkyl, -OR, -SR, -CN, - NO2, -SO2R, -5 SOR, -C (O ) R, -CO2R, - C (O) N (R) 2, -NRC (O) R, -NRC (O) N (R) 2, -NRSO2R, or -N (R) 2； R5 is methyl, t-butyl, -CD3, ** Formula ** R6 is hydrogen, methyl, t-butyl or -CD3； or R5 and R6, together with Z>； = N are ** Formula ** n is 0, 1 or 2； and p is 0 or 1.Un compuesto de fórmula I,**Fórmula** X es CR2； Y es O, S o NR； Z es N； cada R es independientemente hidrógeno, alifático C1-6, arilo C3-10, un anillo carbocíclico saturado o parcialmente insaturado de 3-8 miembros, un anillo heterocíclico de 3-7 miembros que tiene 1-4 heteroátomos seleccionados independientemente de nitrógeno, oxígeno o azufre, o un anillo heteroarilo monocí
