Embodiments of the present disclosure describe a guide extension catheter with a retractable wire. The guide extension catheter may include a proximal shaft having a first outer diameter. The guide extension catheter may further include a distal sheath attached to the proximal shaft and having a second outer diameter greater than the first outer diameter. Further, the distal sheath may have a central lumen defined therein and a secondary lumen formed along a wall surface of the distal sheath.