Provided herein are implantable compositions and methods of use thereof comprising a matrix together with at least one polymer and a therapeutically active agent. The use of these implantable compositions is for the local delivery of therapeutically active agents to treat, ameliorate, or prevent the recurrence of a disease. Technical advantages include increased drug therapeutic index, low systemic release, no adverse effects on post-surgery healing, compliance and non-eroding, high-toleration, easy to use in the standard of care surgery, and easily adaptable to embrace a vast range of therapeutic agents and procedures.
