THE INVENTION RELATES TO A FORMULATION FOR SUPPLEMENTATION ON IMMUNE RESPONSE TO A BIOLOGICAL SUBSTANCE. MORE PARTICULARLY, THE FORMULATION CONSISTS OF ONE OR MORE FORMS 0f VITAMIN E WHICH PROVIDES A SUPPLEMENTATION ON IMMUNE RESPONSE TO TETANUS TOXOID. IN ADDITION, THE PRESENT INVENTION ALSO RELATES ON THE EFFECT OF DIFFERENT TYPES OR VITAMIN E SUCH US TOCOTRIENOL RICH FRACTION, DELTA TOCOTRIENOL AND ALPHA-TOCOPHEROL SUPPLEMENTATION ON IMMUNE RESPONSE TO TETANUS TOXOID VACCINATION.