INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;INSTITUT PASTEUR DE LILLE
发明人:
申请号：
EP16155296.3
公开号：
EP3045529A1
申请日:
2007.03.07
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
