DESAI NEIL P.,데사이, 네일, 피.,SOON SHIONG PATRICK,순-시옹, 패트릭
申请号：
KR1020127028052
公开号：
KR1020130028728A
申请日:
2011.03.28
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
The invention relates to a composition comprising nanoparticles comprising paclitaxel and an albumin for use in a method of treating NSCLC in an individual, wherein the method further comprises administering a platinum-based agent to the individual, and wherein treatment is based upon the NSCLC having one or more characteristics selected from the group consisting of (i) the individual being at least about 70 years old, (ii) differential levels of caveolin-1 (CAV-1), (iii) differential levels of SPARC, (iv) differential levels of hypoxia markers, (v) differential levels of tumor acidity, (vi) differential levels of gp60, (vii) differential levels of thymidylate synthase (TS), (viii) differential levels of S phase kinase-associated protein (Skp2), (ix) differential loss of heterozygosity (LOH) of single nucleotide polymorphism (SNP), (x) differential Kras mutations, (xi) differential methylation of promoter region of tumor-related genes, and (xii) differential albumin uptake.본 발명은 a) 파클리탁셀(paclitaxel) 및 알부민을 포함하는 나노입자를 포함하는 조성물 및 b) 백금-기재 작용제 (예를 들어, 카르보플라틴(carboplatin))을 투여하는 것에 의해 비-소세포 폐암 (NSCLC)을 치료하기 위한 방법 및 조성물을 제공한다. 본 출원은 a) 도세탁셀 및 알부민을 포함하는 나노입자를 포함하는 조성물의 유효량； 및 b) 스테로이드의 유효량을 개체에게 투여하는 것에 의해 전립선암을 치료하는 방법을 또한 제공한다.
