Syed Faiyaz Ahmed Hossainy,Mikael Trollsas,Thierry Glauser,Yiwen Eveleen Tang,Eugene T. Michal
申请号：
US11726647
公开号：
US08518105B2
申请日:
2007.03.21
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A method and apparatus to treat regions of a vessel is described. A protein elastin-based polymer is released from the apparatus to coat the vessel lining as a primary therapy or an adjunct therapy with the delivery and deployment of a stent with or without drug coating. The protein elastin-based polymer may include a triblock structure having an elastin pentapeptide as the flanking block and a hydrophilic variant of the pentapeptide as the middle block. Both the flanking and middle blocks can be modified to change the structural and chemical properties of the polymer. In particular, the protein elastin based polymer is adapted to perform at least one of controlling release of a treatment agent, stimulating endothelial cell growth and stabilizing the vulnerable plaque to prevent rupture of the vulnerable plaque.
