HISAMITSU PHARMACEUTICAL CO.;久光制药株式会社;久光製藥株式會社; INC.;HISAMITSU PHARMACEUTICAL CO., INC.
发明人:
鹤田清美,鶴田清美,山外真嗣,正宝幸喜,正寶幸喜,中西胜,中西勝
申请号：
MOJ000722
公开号：
MOJ000722B
申请日:
2011.11.28
申请国别(地区):
MO
年份:
2012
代理人:
摘要：
The bright Zhi Chi Body for providing tool Prepare with Shen Shrink of this Hair and bonding Elixirs Layer Stickers Elixirs that Layer is closed on the face at least Single of The Zhi Chi Body,The characteristic of The Stickers Elixirs in what,The above-mentioned Zhi Chi Body with Shen Shrink be applied by Real Volume Shrink processing the face Two Needles Woven Woven cloth Agencies at,Above-mentioned bonding Elixirs Layer using The Layer Total Quality amount as base Quasi,Water Yang acid methyl esters containing 10 Quality amount % or more,As Shang Shu Stickers Elixirs the whole,At 40 DEG C of Warm degree,Relative humidity 90% Xia Measuring fixed saturating Wet degree be 1~350g/m2.24hr,The Shang Shu Stickers Elixirs of Will so that above-mentioned bonding Elixirs Layer Tu cloth amount be 50~300g/m2,Jie Touch Mian Plot is the attached 8 little Time of what people Pi Skin of Fang Shi Stickers of 280cm2,The Fan Wai of the average value ± Standard Quasi deviation of AUC0-24 is 3. in above-mentioned water Yang acid methyl esters Xue Pulp0~60.0ng.hr/mL,The Fan Wai of the average value ± Standard Quasi deviation of AUC0-24 is 5000~13000ng.hr/mL in above-mentioned water Yang acid methyl esters Dai Xie object water Yang acid Xue Pulp.本發明提供具備具有伸縮性的支持體及在該支持體的至少單面上層合的黏合劑層的貼劑，該貼劑的特徵在於，上述具有伸縮性的支持體是由實施了捲縮加工的兩面針織織布構成，上述黏合劑層以該層的總質量爲基準，含有10質量％以上的水楊酸甲酯，作爲上述貼劑整體，在溫度40℃，相對濕度90％下測定的透濕度爲1～350g/m2．24hr，將上述貼劑以使上述黏合劑層的塗布量爲50～300g/m2、接觸面積爲280cm2的方式貼附於人的皮膚8小時，上述水楊酸甲酯的血漿中 AUC0-24的平均值±標準偏差的範圍爲3.0～60.0ng．hr/mL，上述水楊酸甲酯的代謝物水楊酸的血漿中AUC0-24的平均值±標準偏差的範圍爲5000～13000ng．hr/mL。
