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porous membrane comprising a biocompatible block copolymer
专利权人:
EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH
发明人:
Neuenschwander, Peter
申请号:
ES06011457
公开号:
ES2669370T3
申请日:
2006.06.02
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Membrane comprising a biocompatible block copolymer having at least two block units that can be obtained by linear polycondensation in the presence of diisocyanate, diacid halide or phosgene of the first block unit that is an α, di-dihydroxy-polyester (IV) with a second block unit selected from the group consisting of a diol (I), an α, ω-dihydroxy-polyester (II), an α, ω-dihydroxy-polyether (III), and the same α, ω-dihydroxy -polyester (IV), in which the diol (I) can be obtained by transesterification of poly - [(R) - (3) -hydroxybutyric acid] or copolymers thereof with 3-hydroxyvaleric acid with ethylene glycol, in which the α , ω-dihydroxy-polyester (II) can be obtained by ring opening polymerization of cyclic esters selected from the group consisting of (L, L) - dilactide, (D, D) -dilactide, (D, L) -dilactide, diglycolide or mixtures thereof, or lactones selected from the group consisting of β- (R) -butyrole actone, β- (S) -butyrolactone, β-rac-butyrolactone and ε-caprolactone or mixtures thereof, wherein the α, ω-dihydroxy-polyether (III) is selected from the group consisting of α, ω- dihydroxy-poly (oxytetramethylene), α, ω-dihydroxy-poly (oxyethylene) and copolymers of ethylene glycol and propylene glycol, in which the α, ω-dihydroxy-polyester (IV) can be obtained by transesterification of α, ω-dihydroxy [oligo (3- (R) -hydroxybutyrate) ethylene-oligo (3- (R) -hydroxybutyrate)] with diglycolide and / or dilactide and / or caprolactone or mixtures thereof, and it is characterized in that the membrane comprises regularly distributed pores and said pores have a size in the range of 0.2 to 20.0 μm.Membrana que comprende un copolímero en bloques biocompatible que tiene al menos dos unidades de bloques que puede obtenerse mediante policondensación lineal en presencia de diisocianato, haluro diácido o fosgeno de la primera unidad del bloque que es un α,ω-dihidroxi-poliéster (IV) con una segunda unidad de bloques seleccionada del grupo que consiste en un diol (I), un
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