The bright Ti of this Hair Gong Fitness be used as acetyl group CoA carboxylase ACC and inhibit be for the compound Ju Body of Elixirs Qi Medical Drug Group of Thienopyrimidine derivative , close object and using its control such as obesity of Treatment Ge Body, blood lipid Iso often, Gao Zhi Quality mass formed by blood stasis, fungi, the infection of Ji Sheng Insect or Fine bacterium Jie ACC Guide illness method. The method that mono- step Ti Gong mono- Seed of this Hair Ming Jin inhibits the ACC in plant, it includes so that the Zhi Wu With is inhibited Elixirs compound Jie Touch.本發明提供適用作乙酰基CoA羧化酶ACC抑制劑的化合物,具體而言是噻吩并嘧啶衍生物,其醫藥組合物以及使用其治療個體的例如肥胖症、血脂異常、高脂質血症、真菌、寄生蟲或細菌感染的ACC介導的病症的方法。本發明進一步提供一種抑制植物中的ACC的方法,其包含使所述植物與抑制劑化合物接觸。