BOUCHARD HERVE,SASSOON,INGRID,MIKOL,VINCENT,COMMERCON ALAIN,FROMOND CLAUDIA,PARKER FABIENNE,TAVARES DANIEL
申请号：
TN2012000115
公开号：
TN2012000115A1
申请日:
2012.03.14
申请国别(地区):
TN
年份:
2013
代理人:
摘要：
The invention relates to a compound of formula (I): wherein : • ALK is a (C1-C6)alkylene group； • X1 et X2are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O)n(n=0,1 or 2) or O-； • R and R' are independently H or a (C1-C6)alkyl group； • I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10； • j is an integer corresponding to 1 when X2is -CH=CH- and 2 when X2 is not -CH=CH-； • Zbis a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group； or Zbis a single bond and Rbis Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.
