Leonardo Puerta Llerena,Luis Caraballo,José Fernando Cantillo
申请号：
US13884482
公开号：
US09163069B2
申请日:
2012.09.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention refers to recombinant DNA molecules encoding fusion peptides from different allergens from Blomia tropicalis and Dermatophagoides pteronyssinus having potential usefulness in prevention and treatment of allergies caused by domestic mites. Specifically, the invention discloses fusion proteins comprising different fragments of allergens Der p 1, Der p 2, Der p 7, Der p 8, Blo t 5, Blo t 8, Blo t 18, Blo t 12 and Blo t 13 with reduced serum IgE reactivity in allergic and non-allergic individuals. It also discloses methods for production of these molecules in an expression system based on E. coli and purification. The invention refers also to effective and safe vaccines.
