The present invention relates to a blind-guide mobile device positioning system and an operation method thereof. When a blind user wears an electronic eyeglasses or is accompanied by a home care robot, the blind-guide mobile device positioning system can assist the blind user in accessing local images by a camera module and assure of a physical location thereof for performing location tracking by a positioning module, so as to allow family members, care units, or police and fire units at remote ends to immediately control a security state of the blind user by a communication module. Besides, the blind user can identify a location thereof through the sound of a sound module, so as to promote the self-care capability with which the requirement of relying on others helps and guidance is not required, thereby guaranteeing the activity safety.本發明係關於一種導盲行動裝置定位系統及其運作方法,其可幫助盲人使用者在穿戴電子眼鏡或者是伴隨著居家照護機器人時,使用攝像模組取得當地的影像,並且透過定位模組確認使用者的所在位置以進行位置追蹤,再經由傳輸模組而讓位於遠端的家屬、照護單位或是警消單位可即時掌握使用者的安全狀況。同時使用者也可藉由音效模組的聲音而得知其所在之處,讓其不倚仗他人扶助引導的能力得以提高,也讓其活動的安全性獲得保障。10‧‧‧可攜式電子配件20‧‧‧監視裝置30‧‧‧使用者40‧‧‧觀察者X‧‧‧近端Y‧‧‧遠端