MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人:
MA, MINGLIN,ANDERSON, DANIEL G.,LANGER, ROBERT S.,VEISEH, OMID,VEGAS, ARTURO JOSE,DOLOFF, JOSHUA CHARLES,CHEN, DELAI,KASTRUP, CHRISTIAN J.
申请号：
CA2985753
公开号：
CA2985753C
申请日:
2014.03.14
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Biomedical devices for implantation with decreased pericapsular fibrotic overgrowth are disclosed. The device includes biocompatible materials and has specific characteristics that allow the device to elicit less of a fibrotic reaction after implantation than the same device lacking one or more of these characteristic that are present on the device. Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
