A surgical cassette for use with a phacoemulsification system having a front housing; and a fluid manifold having an at least partially unibody construction and being removably coupled to at least the front housing. The fluid manifold having molded fluid channels. A surgical system, having a console, a handpiece, and a cassette that couples the handpiece with the console, wherein the cassette has a front housing, a fluid manifold and a drain bag assembly; wherein the fluid manifold has a unibody construction and is removably coupled to at least the front housing and drain bag assembly.