Role of a cluster of long noncoding RNA transcripts in protecting the heart from pathological hypertrophy

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专利权人:

发明人:

Ching-Pin Chang

申请号：

US14884827

公开号：

US09844583B2

申请日:

2015.10.16

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Nucleic acids encoding modified myosin heavy-chain-associated RNA transcripts are provided. The modified myosin heavy-chain-associated RNA transcripts belongs to a cluster of long noncoding RNAs (lncRNA) and bind to chromatin remodeler Brg1 to inhibit Brg1s genomic targeting and gene regulation function. The modified myosin heavy-chain-associated RNA transcripts expressed in an individual inhibit Brg1s gene regulation function and protect the heart of the individual from myopathy and failure. One of the modified heavy-chain-associated RNAs is a 400 base pair fragment segmented from a natural 779 base pair sequence of Mhrt (Mhrt779) and has the same cardioprotective effects as the Mhrt779.

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