LACY, SUSAN E.,雷西 苏珊E,雷西 蘇珊E,FUNG, EMMA,方 艾玛,方 艾瑪,BELK, JONATHAN P.,贝尔克 强纳森P,貝爾克 強納森P,DIXON, RICHARD W.,迪克生 理查W,迪克生 理查W,ROGUSKA, MICHAEL,罗古斯卡 麦克,羅古斯卡 麥克,HINTON, PAUL R.,新顿 保罗R,新頓 保羅R,KUMAR, SHANKAR,古墨
申请号：
TW103113940
公开号：
TW201444869A
申请日:
2006.06.29
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention encompasses IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hIL-12) and/or human IL-23 (hIL-23). Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-12 and/or hIL-23 and neutralize h IL-12 and/or hIL-23 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and/or hIL-23 and for inhibiting hIL-12 and/or hIL-23 activity, e.g., in a human subject suffering from a disorder in which hIL-12 and/or hIL-23 activity is detrimental.本發明涵蓋IL-12p40結合蛋白,尤其是結合人類介白素-12(hIL-12)及/或人類IL-23(hIL-23)之抗體。特定言之,本發明係關於為嵌合、CDR移植抗體及人化抗體。較佳抗體對hIL-12及/或hIL-23具有高親和力,且在活體外及活體內可中和hIL-12及/或hIL-23之活性。本發明抗體可為全長抗體或其抗原結合部分。本發明亦提供本發明抗體之製造方法及使用方法。本發明抗體或抗體部分可用以(例如)偵測身受hIL-12及/或hIL-23活性有害之病症的人類受檢者體內hIL-12及/或hIL-23,及用以抑制hIL-12及/或hIL-23之活性。
