FELLOWS ADRIAN NEVILLE,HALLINAN MARK JAMES,MISTRY DHARMIT
申请号：
IN201637036598
公开号：
IN201637036598A
申请日:
2016.10.25
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
A liquid antimicrobial composition is provided for use in the disinfection of the skin of a human or an animal in particular where disinfection of a drug resistant organism is required. The composition comprises a cationic cell membrane disrupting biocide and a cationic dendrimer capable of inhibiting an efflux pump mechanism of said cell membrane. The cationic cell membrane disrupting biocide is preferably any or a combination of chlorhexidine a polymeric biguanide octenidine dihydrochloride and a quaternary ammonium compound. The dendrimer is provided to bind and disrupt the cell membranes of microorganisms in order to inhibit or destroy the cell s efflux pump mechanism thereby preventing microorganism strains resistant to the cationic membrane disrupting biocide from becoming prevalent particularly if the biocide comprises chlorhexidine. The dendrimer is preferably a G o to G 3 dendrimer comprising any or a combination of quaternary ammonium functionalised poly(propylene imine) polylysine dendrimers with surface groups based on a sugar and polyamide amine (PAMAM) dendrimers. The composition is preferably in the form of an aqueous or aqueous alcohol solution dispersion or emulsion that may have been adsorbed by a wipe.
