The present invention is directed to the combination therapy of an afucosylated anti-CD20 antibody with an anti-VEGF antibody for the treatment of cancer, especially to the combination therapy of CD20 expressing cancers with an afucosylated humanized B-Ly1 antibody and an anti-VEGF antibody.本発明は癌の治療のための抗VEGF抗体とのアフコシル化抗CD20抗体の併用療法、特にアフコシル化ヒト化B-Ly1抗体及び抗VEGF抗体を用いたCD20発現癌の併用療法に関する。