Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting

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专利权人:

ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人:

Arnaud Chevalier,Omar Khdour,Yanmin Zhang,Sidney Hecht

申请号：

US16310305

公开号：

US10604501B2

申请日:

2017.06.13

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention relates to the use of prodrugs susceptible to nitroreductase (NTR) activation. In particular, provided herein are mitochondria-targeting prodrug compounds and probes, including profluore scent near-infrared (NIR) probes and non-fluorescent prodrugs, as well as to methods of using said prodrug compounds and probes for imaging mitochondria and for mitochondria-specific delivery of therapeutic agents.

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